Start: Institute of Molecular Regenerative Medicine
Scientific Symposium and Opening Ceremony of the Institute of Molecular Regenerative Medicine
11.09.2009
Scientific Symposium and Opening Ceremony of the Institute of Molecular Regenerative Medicine
Further Information

Institute of Molecular Regenerative Medicine

Publications

List of Publications

2009

  • Rivera FJ., Siebzehnrubl FA. Kandasamy M., Couillard-Despres S., Caioni  M.,          Poehler AM., Berninger B., Sandner B., Bogdahn U. Goetz M., Bluemke  I., Weidner N., Aigner L. (2009) Mesenchymal Stem Cells Promote Oligodendroglial Differentiation in Hippocampal Slice Cultures. Cell Physiol. Biochem. 24:317-324.
  • Winner B., Desplats P., Hagl C., Klucken J., Aigner R., Ploetz S., Laemke J., Karl A., Aigner L., Masliah E., Buerger E., Winkler J. (2009) Dopamine receptor activation promo-tes adult neurogenesis in an acute Parkinson model. Exp. Neurology 219: 543-552.  
  • Wagner K., Couillard-Despres S., Lehner B., Brockhoff G., Rivera FJ., Blume A., Neu-mann I., Aigner L. (2009) Prolactin Induces MAPK Signaling in Neural Progenitors with-out Alleviating Glucocorticoid-Induces Inhibition of in vitro Neurogenesis. Cell Physiol Biochem; 24:397-406.   
  • Torner L., Karg S., Blume A., Kandasamy M., Kuhn H-G., Winkler J., Aigner L., Neumann I. (2009) Prolactin Prevents Chronic Stress-Induced Decrease of Adult Hippocampal Neurogenesis and Promotes Neuronal Fate. J. Neuroscience 29(6): 1826-1833  
  • Marxreiter F., Nuber S., Kandasamy M., Klucken J., Aigner R., Burgmayer R., Couillard-Despres S., Riess O., Winkler J., Winner B. (2009) Changes in adult olfactory bulb neu-rogenesis in mice expressing the A30P mutant form of alpha-synuclein. J. Neuroscience 29, 879-890.
  • Stefanova N., Hainer M., Stemberger S., Couillard-Despres S., Aigner L., Poewe W., Wenning G. (2009) Striatal transplantation for multiple system atrophy – Are grafts af-fected by α-synucleinopathy? Exp. Neurology (Epub ahead of print)
  • Couillard-Despres S., Wuertinger C., Kandasamy M., Caioni M., Stadler K., Aigner R., Bogdahn U., Aigner L. (2009) Ageing Abolishes the Effects of Fluoxetine on Neurogene-sis. Mol. Psychiatry. Jan 13. [Epub ahead of print]
  • Couillard-Despres S., Wuertinger C., Kandasamy M., Caioni M., Stadler K., Aigner R., Bogdahn U., Aigner L. (2009)
    Ageing Abolishes the Effects of Fluoxetine on Neurogenesis. Mol. Psychiatry. Jan 13. [Epub ahead of print]

2008

  • Ramm P, Couillard-Despres S, Plötz S, Rivera FJ, Krampert M, Lehner B, Kremer W, Bogdahn U, Kalbitzer HR, Aigner L. (2008)
    A NMR Biomarker for Neural Progenitor Cells: Is It All Neurogenesis? Stem Cells 2008 Nov 6. [Epub ahead of print].
  • Rivera FJ, Kandasamy M, Couillard-Despres S, Caioni M, Sanchez R, Huber C, Weidner N, Bogdahn U, Aigner L. (2008)
    Oligodendrogenesis of Adult Neural Progenitors: Differential Effects of Ciliary Neurotrophic Factor and Mesenchymal Stem Cell Derived Factors. J Neurochem. 107(3):832-43.
  • Mueller AM, Pedré X, Stempfl T, Kleiter I, Couillard-Despres S, Aigner L, Giegerich G, Steinbrecher A. (2008)
    Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis. J Neuroinflammation. 5: 20.
  • Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brüstle O. (2008)
    Lineage Selection of Functional and Cryopreservable Human Embryonic Stem Cell-Derived Neurons. Stem Cells. 26(7):1705-12.
  • Couillard-Després S., Winner B., Plötz S., Wiedermann D., Aigner R., Bogdahn U., Winkler J., Hoehn M., Aigner L. (2008)
    In vivo optical imaging of neurogenesis - Watching new neurons in the intact brain. Molecular Imaging. 7(1): 28-34.
  • Couillard-Despres S., Quehl E., Karl C., Ploetz S., Bogdahn U., Winkler J., Aigner L. (2008) In vitro reporter model of neuronal development and early differentiation processes. BMC Neuroscience. 9: 31.
  • Winner B., Couillard-Despres S., Geyer M., Aigner R., Bogdahn U., Aigner L., Kuhn G., Winkler J. (2008).
    Dopamiergic lesion enhances growh factor-induced striatal neuroblast migration. J Neuropath Exp Neurol, 67(2): 105-16.
  • Aigner L. & Bogdahn U. (2008)
    TGF-beta in neural stem cells and in tumors of the central nervous system. Cell Tissue Res. 331(1): 225-41.

2007

  • Hehr U, Uyanik G, Gross C, Walter MC, Bohring A, Cohen M, Oehl-Jaschkowitz B, Bird LM, Shamdeen GM, Bogdahn U, Schuierer G, Topaloglu H, Aigner L, Lochmuller H, Winkler J (2007)
    Novel POMGnT1 mutations define broader phenotypic spectrum of muscle-eye-brain disease. Neurogenetics. 8(4): 279-88.
  • Beier, D., Hau, P., Proescholdt, M., Lohmeier, A., Wischhusen, J., Oefner, P.J., Aigner, L., Brawanski, A., Bogdahn, U. & Beier, C.P. (2007)
    CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res, 67: 4010-4015.
  • Kohl, Z., Kandasamy, M., Winner, B., Aigner, R., Gross, C., Couillard-Despres, S., Bogdahn, U., Aigner, L. & Winkler, J. (2007)
    Physical activity fails to rescue hippocampal neurogenesis deficits in the R6/2 mouse model of Huntington's disease. Brain Res, 1155: 24-33.
  • Uyanik, G., Morris-Rosendahl, D.J., Stiegler, J., Klapecki, J., Gross, C., Berman, Y., Martin, P., Dey, L., Spranger, S., Korenke, G.C., Schreyer, I., Hertzberg, C., Neumann, T.E., Burkart, P., Spaich, C., Meng, M., Holthausen, H., Ades, L., Seidel, J., Mangold, E., Buyse, G., Meinecke, P., Schara, U., Zeschnigk, C., Muller, D., Helland, G., Schulze, B., Wright, M.L., Kortge-Jung, S., Hehr, A., Bogdahn, U., Schuierer, G., Kohlhase, J., Aigner, L., Wolff, G., Hehr, U. & Winkler, J. (2007)
    Location and type of mutation in the LIS1 gene do not predict phenotypic severity. Neurology, 69: 442-447.

2006

  • Couillard-Despres S., Winner B., Karl C., Lindemann G., Schmid P., Aigner R., Laemke J., Bogdahn U., Winkler J., Bischofberger J., Aigner L. (2006).
    Targeted transgene expression in neuronal precursors: watching young neurons in the old brain. European Journal of Neuroscience. 24(6): 1535-45.
  • Rivera F., Couillard-Despres S., Pedre-Villareal X., Ploetz S., Lois C., Bogdahn U., Aigner L. (2006).
    Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells. Stem Cells. 24(10): 2209-19.
  • Rivera F., Sierralta W.D., Minguell J., Aigner L. (2006).
    Adult hippocampus derived soluble factors induce a neuronal-like phenotype in mesenchymal stem cells. Neuroscience Letters. 406: 49-54.
  • Pfeifer K., Vroemen M., Caioni M., Aigner L., Bogdahn U., Weidner N. (2006).
    Autologous adult neural progenitor cell transplantation represents a feasible strategy to promote structural repair in the chronically injured spinal cord. Regenerative Medicine. 1(2): 255-66.
  • Wachs F.-P., Winner B., Couillard-Despres S., Schiller T., Aigner R., Winkler J., Bogdahn U., and Aigner L. (2006).
    Transforming growth factor-b1 is a negative modulator of adult neurogenesis. J. Neuropath. Exp. Neurol. 65(4): 358-70.
  • Winner B., Geyer M., Couillard-Despres S., Aigner R., Bogdahn U., Aigner L., Kuhn G., Winkler J. (2006).
    Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb. Exp Neurol. 197: 113-21.

2005

  • Engelhardt M., Bogdahn U., Aigner L. (2005).
    Adult retinal pigment epithelium cells express neural progenitor properties and the neuronal precursor protein doublecortin. Brain Res, 1040: 98-111.
  • Couillard-Despres S., Winner B., Schaubeck S., Aigner R., Vroemen M., Weidner N., Bogdahn U., Winkler J., Kuhn H.-G., Aigner L. (2005). Doublecortin expression levels in adult brain reflect neurogenesis. Eur. J. Neurosci, 21: 1-14. 
  • Karl C., Couillard-Despres S., Prang P., Munding M., Kilb W., Brigadski T., Plötz S., Mages W., Luhmann H., Winkler J., Bogdahn U., Aigner L. (2005).
    Neuronal precursor specific activity of a human doublecortin regulatory sequence. J. Neurochem, 92: 264-282.

1992 - 2004

  • Winner B., Lie C., Rockenstein E., Aigner R., Aigner L., Masliah E., Kuhn H.-G., Winkler J. (2004).
    Human wild-type a-synuclein impairs neurogenesis. J. Neuropath. Exp. Neurol., 63: 1155-1166.
  • Schänzer A., Wachs F.-P., Wilhelm D., Acker T., Cooper-Kuhn C., Beck H., Winkler J., Aigner L., Plate K.H., Kuhn H.G. (2004).
    Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor. Brain Pathology, 14: 237-248.
  • Couillard-Despres S., Uyanik G., Ploetz S., Karl C., Stefan H., Winkler J., Aigner L. (2004).
    Mitotic impairment by doublecortin is diminished by doublecortin mutations found in patients. Neurogenetics. 5: 83-93.
  • Engelhardt M., Wachs F.-P., Couillard-Despres S., Aigner L. (2004).
    The neurogenic competence of progenitors from the postnatal retina in vitro. Experimental Eye Research, 8: 1025-36.
  • Lange M., Winner B., Müller J.L., Marienhagen J., Schröder M., Aigner L., Uyanik G., Winkler J. (2004).
    Functional imaging in PNH caused by a new filamin A mutation. Neurology, 62: 151-2.
  • Vroemen M., Aigner L., Winkler J., Weidner N. (2003).
    Adult neural progenitor cell grafts survive after acute spinal cord injury and integrate into axonal pathways. European Journal of Neuroscience, 18: 743-51.
  • Brown J., Couillard-Despres S., Cooper-Kuhn C., Winkler J., Aigner L., Kuhn H.-G. (2003).
    Transient expression of doublecortin during adult neurogenesis. Journal of Comparative Neurology, 467: 1-10.
  • Uyanik G., Aigner L., Martin P., Hehr U., Gross C., Marschner-Schaefer H., Winkler J. (2003).
    ARX mutations in X-linked lissencephaly with ambiguous genitalia (XLAG). Neurology, 61: 232-235
  • Wachs F.-P., Couillard-Despres S., Engelhardt M., Wilhelm D., Ploetz S., Vroemen M., Kaesbauer J., Uyanik G., Klucken J., Karl C., Tebbing J., Svendsen C.N., Weidner N., Kuhn H.-G., Winkler J., Aigner L. (2003).
    High efficacy of clonal growth and expansion of adult neural stem cells. Lab. Invest., 83: 949-962.
  • Aigner L., Uyanik G., Couillard-Despres S., Ploetz S., Wolff G., Morris-Rosendahl D, Martin P., Eckel J., Spranger S., Otte J., Woerle H., Holthausen H., Apheshiotis N., Flügel D., Winkler J. (2003).
    Somatic mosaicism and variable penetrance in Doublecortin-associated migration disorders. Neurology, 60: 329-332.
  • Becker A.J., Klein H., Baden T., Aigner L., Normann S., Elger C.E., Schramm J., Wiestler O.D., Blumcke I. (2002).
    Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas. Acta Neuropathol (Berl). 104: 403-8.
  • Kohl Z., Kuhn H.-G., Cooper-Kuhn C., Winkler J., Aigner L., Kempermann G. (2002).
    Preweaning enrichment has no lasting effects on adult hippocampal neurogenesis in four-month old mice. Genes, Brain and Behavior, 1: 46-54.
  • Couillard-Despres S., Winkler J., Uyanik G., Aigner L. (2001).
    Molecular mechanisms of neuronal migration disorders, Quo Vadis? Current Molecular Medicine, 1: 677-688.
  • Aigner L., Fluegel D., Dietrich J., Ploetz S., Winkler J. (2000).
    Isolated lissencephaly sequence and double cortex syndrome in a german family with a novel doublecortin mutation. Neuropediatrics, 31: 195-198. 
  • Di Polo A.*, Aigner L. *, Dunn R.J., Bray G.M., Aguayo A.J. (1998).
    Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells. Proc. Natl. Acad. Sci. USA, 95: 3978-3983. *: equal contribution
  • Caroni P., Aigner L., Schneider C. (1997).
    Intrinsic neuronal determinants locally regulate extrasynaptic and synaptic growth at the adult neuromuscular junction. J. Cell Biol., 136(3): 679-692.
  • Aigner L., Arber S., Kapfhammer J. P., Laux T., Schneider C., Botteri F., Brenner H.-R., Caroni P. (1995).
    Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice. Cell, 83: 269-278.
  • Aigner L. and Caroni P. (1995).
    Absence of persistent spreading, branching, and adhesion in GAP-43-depleted growth cones. J. Cell Biol., 128: 647-660.
  • Aigner L. and Caroni P. (1993).
    Depletion of 43-kD growth-associated protein in primary sensory neurons leads to diminished formation and spreading of growth cones. J. Cell Biol., 123(2): 417-429.
  • Hohmann H.-P., Remy R., Aigner L., Brockhaus M., van Loon A. P. G. M. (1992).
    Protein kinases negatively affect nuclear factor-kB activation by Tumor Necrosis Factor-a at two different stages in promyelotic HL60 cells. J. Biol. Chem., 267: 2065-2072.
  • Deloukas P., Aigner L., Kania M., van Loon A. P. G. M. (1992).
    Construction of yeast artificial chromosome (YAC) clone banks covering three genome equivalents and isolation of YACs containing the human gene encoding tumor necrosis factor receptor beta. Gene, 110: 189-195.

Book Chapters and Review Articles

  • Uyanik, Aigner, Couillard-Despres, Hehr, Winkler. (2007).
    DCX Related Disorders. http://www.genetests.org/
  • Aigner L., Karl C. (2007).
    Retinal Research: Application to Clinical Practice, in Birgit Lorenz and Francois-Xavier Borrua "Pediatric Ophthalmology, Neuro-Ophthalmology, Genetics". 
  • Aigner L., Winkler J., Bogdahn U. (2007).
    Schutz oder Neuaufbau: Neuroprotektive Effekte des Transforming Growth Faktors-beta1 auf Kosten einer reduzierten Neurogenese?. Neuroforum 1(07): 4-12.
  • Aigner L., Klucken J., Weidner N., Kuhn H.-G., Winkler J. (2002)
    Adulte neurale Stammzellen: Zellersatz für das Nervensystem. Der Neurologe und Psychiater; 5/02: 30-34.
  • Uyanik G., Hehr U., Aigner L., Winkler J. (2003).
    Neuronale Migrationsstörungen: Klinik und Molekulargenetik der Lissenzephalien. Aktuelle Neurologie, 30:1-7. 
  • Uyanik G., Winkler J., Aigner L. (2002).
    Malformationen, in Schoels L., Riess O. Neurogenetik, Kohlhammer, Stuttgart, 215-230.
  • Kuhn H.-G., Weidner N., Winkler J., Aigner L. (2002).
    Somatische Stammzellen des Zentralnervensystems. Bundesgesundheitsblatt-Gesundheitsforschung-
    Gesundheitsschutz; 45: 92-101.
  • Aigner L., Kuhn, H.-G., Weidner N., Winkler J. (2001).
    Adulte neurale Stammzellen – Zelltherapie der Zukunft in der Neurologie? Biotechnologie in Bayern, 60-64. 

Patent Applications

  • Couillard-Despres S., Karl C., Kuhn H.-G., Aigner L. Use of regulatory sequence for specific, transient expression in neuronal determined cells. WO 2004067751
  • Bogdahn U., Wachs F.-P., Winner B., Winkler J., Aigner L. Inhibitor of TGF-beta1 /TGF-R signaling for treatment of neurodegenerative diseases. WO 2005074981A2.