Scientific Research Institutes > University Institutes > Tendon and Bones Regeneration

Institute for Tendon and Bone Regeneration

Head: Priv.-Doz. Mag. Dr. Andreas Traweger



Founding

The Institute for Tendon and Bone Regeneration originates from a research initiative for cell biology and was founded at the end of 2011 by Univ.-Prof. Dr. Herbert Resch, Rector of Paracelsus Medical Private University and Senior Consultant of the University Hospital for Trauma Surgery and Sports Traumatology. This was possible by an endowment by three sponsors – Red Bull GmbH, Rauch GmbH and Rexam PLC, which have financed the institute first for five years. Univ.-Doz. Dr. Hans-Christian Bauer was entrusted as a research professor with the management of the institute for the duration of three years. The work group around Bauer was taken over in the institute and thus the long cooperation between the head of the institute, its employees and the rector was strengthened and expanded.


Objective

The name of the new institute reveals its goal: to develop new treatment strategies for defective/damaged tendons and bones, in order to restore their functionality as far as possible. These strategies have to do very often with the potential of the plastic precursor cells which differentiate themselves during the regeneration process in cells with clearly specific functions. In this way, the own healthy cells of the body can be attracted and stimulated. Alternatively, the damaged cells and tissues can be replaced by transplantation. Generally, we follow the "From Bench to Bedside" philosophy and focus primarily on the research of the fundamental mechanisms of the tendons and bone degeneration and their correction. This is done both in vitro and in vivo, in order to be able as a result to develop therapeutic strategies for tissue regeneration.

Research projects and methods

Projects

There are already several strategies that are applied in the hospital in order to accelerate the regeneration of the bones, but, as before, new ways were desirable. Certain pathological conditions in the bones can still not be explained and require scientific research. On the other hand, the regeneration of the tendons is still very little understood and in the recent decades it was often neglected. Therefore, the need to research the regeneration capabilities of the tendons is obvious – and, due to the increasing ageing of the population, is becoming even more urgent. One of the possible strategies in both tissues is the use of precursor cells. Therefore, our projects will answer the questions about the nature and the effectiveness of these cells and what significant role they can play in the regeneration. In addition, in the tendon area, the fundamental research of the tendon cells is important and also to what extent their precursor cells play a role in the healthy and the damaged tendons.

 

Currently running projects:

  • The properties of the perivascular tendon cells in vitro and in vivo
  • The effect of age and gender on the stability of the tendons and the build-up of the tendon and bone structures, in particular of the osteocytes
  • The comparison of the mesenchimales stem cells with tendon precursor cells (TDSCs)
  • Establishing the suitable animal models in order to be able to analyse the regeneration models

Sparkling Science


Project: Exciting regeneration research – development of a new type of bioreactor for the cultivation of tendons

The injuries and chronic diseases of tendons and ligaments are a big challenge for surgery and there is an urgent need for helpful and quickly effective therapies for the functional tendon regeneration. The tendons are collagen-rich connective bands which are subjected to high mechanical forces, contain relatively small number of cells and because of that they heal very slowly and incompletely. Compared to the tissues with high regenerative potential (e.g. skin or bones), after an injury no functional tissue is formed but in fact cicatrisation occurs. The resulting changes reduce the mechanical properties of the tendons and often it comes to secondary injuries.

In order to be able to develop more effective therapy methods, first the biomechanical and biological processes, which are the cause for the low regeneration capability of the tendons, must be understood. The objective of the project is to build, jointly with the Higher Technical Federal College and Research Institute (HTBLuVA Salzburg; focus of training: biomedicine and healthcare technology) a bioreactor for the organotypical tendon culture which permits continuous measurement of the biomechanical properties of the tendons of rats in vitro. In collaboration with the students of HTBLuVA Salzburg, a bioreactor is going to be built, which permits to cultivate tendon tissue under cyclical or constant tension in vitro and thereby to measure its mechanical changes. The planning and the technical realisation of the bioreactor is done by the students within the framework of their diploma thesis. Thereby there are various "experimental modules" to be realised such as, for example, a mechanical loading and testing module, a module for calibrated tension-based testing as well as the necessary sensors and measurement data logging. In the second phase of the project, the students have an opportunity to operate the bioreactor in the Paracelsus Medical University Salzburg and research various scientific issues. In this way, they have the possibility to learn the real scientific research work in the area of the basic medical research and thus to enter deeper in the use of the bioreactor constructed by them.

The in-vitro culture of tendons in this bioreactor makes possible the research of the cellular, biomechanical and molecular biology changes under various controlled conditions. One test approach must research the effects of the thrombocyte lysate (PRP) on the quality of the tendons, because different tendon diseases are treated often with PRP. However, some advantages of this treatment are still discussed in controversy. The organotypical culture offers the possibility to research the tendons under almost physiological conditions, because only under these conditions the tendon cells embedded in the collagen matrix are screened by a cellular barrier that is similar to the one in vivo.


Project: What tendons want: The influence of the nutrition on the musculoskeletal system

The tendons are important component part of the musculoskeletal system and serve as connection and force transmitters between the muscles and the bones. They are very elastic and at the same time have high tensile strength. Histologically, the tendon tissue is considered as tight connecting tissue with parallel fibres, which is distinguished by its high collagen content and low cell density. In addition, the tendons have a very small regeneration/healing potential.

Sports accidents, but also household or workplace accidents are the cause of injuries of the support and musculoskeletal system. Along with this, injuries of the tendons and bands often occur, such as, for example, Achilles tendon ruptures in soccer players, cruciate ligament ruptures in skiers or injuries of the rotator cuff of the shoulders after physical overloads or falls.

Usually with the old age the quality of the tendons decrease. In addition, intrinsic factors also play a role (e.g. gender, weight, chronic diseases and their medication of) as well as extrinsic factors (e.g. loading and overloading through physical activities and way of life) play a role in the degeneration of the tendons. The current works contain also indications that the blood sugar level also has an effect on the tendon properties. Our work group at Paracelsus Medical University was able to show that the tendon cells produce insulin and react with this release to the increase in the glucose level in the environment.

In this project,the effect of factors such as nutrition – in particular of glucose-rich food – both on the quality of the extracellular matrix and the microstructure and function of the tendons is going to be researched. Thereby molecular biology, histological and biomechanical methods of analysis are used to this purpose. Many of these analyses will be made jointly with the students of the Europe and Federal Grammar School Salzburg-Nonntal (Karlheinz-Böhm Grammar School) and the Bundesgymnasium & Bundesrealgymnasium Hallein. Within the framework of the biology elective subject, the students receive an overview of the structure and functioning of the musculoskeletal system, which otherwise is at a higher level than the level taught in the regular school education. In addition, they receive an overview of the work in a laboratory for molecular biology, cell biology and histology and also access to a scientific research workplace outside of the school. They partially plan experiments individually as well as perform and evaluate experiments under the supervision of a scientist.

The objective of the project is to study the effect of the nutrition-based sugar intake on the molecular and cellular properties of the tendon cells and tendon tissue and possibly to create the scientific groundwork for a form of conservative therapy (such as, for example, a special diet) which can influence favourably the functional regeneration of the tendons after an injury.

Publications

2013

Traweger, A, Toepfer S, Wagner RN, Zweimueller-Mayer J, Gehwolf R, Lehner L, Tempfer H, Krizbai I, Wilhelm I, Bauer HC, Bauer H. Beyond cell-cell adhesion – emerging roles of the tight junction scaffold ZO-2; Tissue Barriers; accepted

O’Rourke M*, Traweger A*, Lusa L, Stupica D, Maraspin V, Barrett PN, Strle F, Livey I (2013). Quantitative detection of Borrelia burgdorferi sensu lato in erythema migrans skin lesions using an internally controlled duplex real time PCR. PLOS One; accepted (*equal contribution)

Lehner C, Gehwolf R, Hirzinger C, Stephan D, Augat P, Tauber M, Resch H, Bauer HC Bauer H, Tempfer H (2013) Bupivacaine induces short term alterations and impairment in rat tendons. Am J Sports Med.; Jun;41(6):1411-8

Lange S, Trost A, Tempfer H, Bauer HC, Bauer H, Rohde E, Reitsamer HA, Franklin RJ, Aigner L, Rivera FJ. (2013) Brain pericyte plasticity as a potential drug target in CNS repair. Drug Discov Today. May;18(9-10):456-63

2012

Lehner C, Gehwolf R, Wagner A, Resch H, Hirzinger C, Augat P, Stephan D, Aigner L, Rivera FJ, Bauer HC, Tempfer H. (2012) Tendons from Non-diabetic Humans and Rats Harbor a Population of Insulin-producing, Pancreatic Beta Cell-like Cells. Horm Metab Res, 44(7):506-10

Liddelow S., Temple S., Møllgård K., Gehwolf R., Wagner A., Bauer H., Bauer H.C., Phoenix T., Dziegielewska K., Saunders N. (2012). Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach. PlosOne, 7(3): e33554

Eberhard N, Mayer C, Santic R, Navio RP, Wagner A, Bauer HC, Sperk G, Boehm U, Kofler B. (2012). Distribution of alarin immunoreactivity in the mouse brain. J Mol Neurosci. Jan;46(1):18-32

Krizbai I, Wilhelm I, Bauer H.C. and Bauer H .(2012). The Role of Glia in the Formation and Function of the Blood-Brain Barrier. Neuroglia, 3rd Edition, Edited by Helmut Kettenmann and Bruce R. Ransom, Oxford University Press. Pp 343-352.

Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K, Schnidar H, Hache H, Bauer HC, Solca F, Hauser-Kronberger C, Ermilov AN, Verhaegen ME, Bichakjian CK, Dlugosz AA, Nietfeld W, Sibilia M, Lehrach H, Wierling C, Aberger F. (2012). Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells.EMBO Mol Med. Mar;4(3):218-33

Fritz R, Orlinger KK, Hofmeister Y, Janecki K, TRAWEGER A, Perez-Burgos L, Barrett PN, Kreil TR (2012). Quantitative comparison of the cross-protection induced by tick-borne encephalitis virus vaccines based on European and Far Eastern virus subtypes. Vaccine; 30 (6):1165-9

2011

Huber C, Marschallinger J, Tempfer H, Furtner T, Couillard-Despres S, Bauer HC, Rivera FJ, Aigner L. Inhibition of leukotriene receptors boosts neural progenitor proliferation. Cell Physiol Biochem, 2011;28(5):793-804

Lehner C, Gehwolf R, Tempfer H, Krizbai I, Hennig B, Bauer HC, Bauer H (2011) Oxidative stress and blood-brain barrier dysfunction under particular consideration of matrix metalloproteinases. Antioxid Redox Signal. 1;15(5):1305-23

Bauer HC, Traweger A, Zweimueller-Mayer J, Lehner C, Tempfer H, Krizbai I, Wilhelm I, Bauer H. (2011) New aspects of the molecular constituents of tissue barriers. J Neural Transm, 118(1):7-21

Lehner B, Sandner B, Marschallinger J, Lehner C, Furtner T, Couillard-Despres S, Rivera FJ, Brockhoff G, Bauer HC, Weidner N, Aigner L. (2011) The dark side of BrdU in neural stem cell biology: detrimental effects on cell cycle, differentiation and survival. Cell Tissue Res, 345(3):313-28.

Eberhard N, Mayer C, Santic R, Navio RP, Wagner A, Bauer HC, Sperk G, Boehm U, Kofler B. (2011). Distribution of Alarin Immunoreactivity in the Mouse Brain. J Mol Neurosci. Jun 7.

Livey I, O'Rourke M, Traweger A, Savidis-Dacho H, Crowe BA, Barrett PN, YangX, Dunn JJ, Luft BJ (2011). A new approach to a lyme disease vaccine. Clin Infect Dis.; 52 Suppl 3:s266-70.

2010

Tempfer H, Hofmann W, Schober A, Lettner H, Dinu AL (2010) Deposition of radon progeny on skin surfaces and resulting radiation doses in radon therapy. Radiat Environ Biophys, 49(2):249-59.

Bauer H, Zweimueller-Mayer J, Steinbacher P, Lametschwandtner A, Bauer HC. (2010). The dual role of zonula occludens (ZO) protein. J. Biomed Biotechnol. 402593

Bueter W, Saunders NR, Mallard C, Bauer HC, Stolp HB, Kavelaars A, Dammann O; NEUROBID consortium. (2010).Int J Dev Neurosci. Aug;28(5):411-2.

2009

Tempfer H*, Gehwolf R*, Lehner C, Wagner A, Mtsariashvili M, Bauer HC, Resch H, Tauber M, (2009), Effects of crystalline glucocorticoid triamcinolone acetonide on cultured human supraspinatus tendon cells. Acta Orthop, 80(3):357-62. (*equal contribution)

Lehner C, Kerschbaum HH, Lütz-Meindl U (2009). Nitric oxide suppresses growth and development in the unicellular green alga Micrasterias denticulata. , 2009 Jan 30;166(2):117-27

Tempfer H*, Wagner A*, Gehwolf R, Lehner C, Tauber M, Resch H, Bauer HC. (2009) Perivascular cells of the supraspinatus tendon express both tendon- and stem cell related markers. Histochem Cell Biol, 131(6):733-41 (*equal contribution)

2008

Traweger A., Lehner C. Bauer HC, Tempfer H., Guenter B., Krizbai I., Farkas A. Bauer H. (2008) Nuclear ZO-2 alters gene expression and junctional stability in epithelial and endothelial cells. Differentiation, 76(1):99-106

Sommer A, Geist B, Da Ines O, Gehwolf R, Schäffner AR, Obermeyer G (2008). Ectopic expression of Arabidopsis thaliana plasma membrane intrinsic protein 2 aquaporins in lily pollen increases the plasma membrane water permeability of grain but not of tube protoplasts. New Phytol, 180(4): 787-97

Traweger A, Wiggin G, Taylor L, Tate SA, Metalnikov P, Pawson T (2008). Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3. PNAS, 105(30):10402-7

Wilhelm I, Nagyoszi P, Farkas AE, Couraud PO, Romero IA, Weksler B, Fazakas C, Dung NT, Bottka S, Bauer H, Bauer HC, Krizbai IA. (2008). Hyperosmotic stress induces Axl activation and cleavage in cerebral endothelial cells. J Neurochem. Oct;107(1):116-26

2007

Gehwolf R*, Weiss R*, Gabler M, Hurst AC, Bertl A, Thalhamer J, Obermeyer G (2007). From sequence to antibody: genetic immunisation is suitable to generate antibodies against a rare plant membrane protein, the KAT1 channel. FEBS Letters, 581(3): 448-52 (*equal contribution)

Steinbacher P, Haslett JR, Obermayer A, Marschallinger J, Bauer HC, Sänger AM, Stoiber W. (2007). MyoD and Myogenin expression during myogenic phases in brown trout: a precocious onset of mosaic hyperplasia is a prerequisite for fast somatic growth. Dev Dyn. Apr;236(4):1106-14

2006

Bresgen N, Jaksch H, Bauer HC, Eckl P, Krizbai I, Tempfer H (2006). Astrocytes are more resistant than endothelial cells towards geno- and cytotoxicity mediated by short term oxidative stress. J Neurosc Res, 84(8):1821-8

Bauer HC, Tempfer H, Bernroider G, Bauer H. (2006) Neuronal stem cells in adults. Exp Gerontol, 41(2):111-6.

Wells CD *, Fawcett JP *, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T (2006). A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell, 125(3):535-48. (*equal contribution)

Rinninger, A., Richet, C., Pons, A., Kohla, G., Schauer, R., Bauer, H.C., Zanetta, J.P. and Vlasak R. (2006). Localisation and distribution of O-acetylated N-acetylneuraminic acids, the endogenous substrates of the hemagglutinin-esterases of murine coronaviruses, in mouse tissue. Glycoconjugate Journal, 23, 1-2, 73-84.

2005

Pertl H, Gehwolf, R, Obermeyer G (2005). The distribution of membrane-bound 14-3-3 proteins in organelle-enriched fractions of germinating lily pollen tubes. Plant Biol, 7: 140-47

Farkas A, Szatmari E, Orbok A, Wilhelm I, Wejksza K, Nagyoszi P, Hutamekalin P, Bauer H, Bauer HC, Traweger A, Krizbai IA (2005). Hyperosmotic mannitol induces Src kinase-dependent phosphorylation of beta-catenin in cerebral endothelial cells. J Neurosci Res., 80(6):855-61

Krizbai IA, Bauer H, Bresgen N, Eckl PM, Farkas A, Szatmari E, Traweger A, Wejksza K, Bauer HC (2005). Effect of oxidative stress on the junctional proteins of cultured cerebral endothelial cells. Cell Mol Neurobiol., 25(1):129-39

Haseloff, RE, Blasig, IE, Bauer, HC, Bauer H. (2005). In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro. Cell. Mol. Neurobiol., Vol. 25, Nr. 1 25-40

Krizbai, IA, Lenzser, G, Szantmari, E, Farkas, Al, Wilhelm, I, Fekete, Z, Erdos, B, Bauer, H, Bauer, HC, Sandor, P, Komjati, K (2005). Blood-brain barrier changes during compensated and decompensated haemorrhagic shock. Shock 24 (5) 428-433

Bauer, H, Bauer HC, Haseloff, RF, Blasig I (2005). The role of glia in the formation of the blood-brain-barrier (BBB). In “Glia” . Edt.H.O. Kettenmann and B.R. Ransom, Oxford Univ. Press, pp 325-333.

2004

Obermeyer G, Gehwolf R, Sebesta, W, Hamilton N, Gadermaier G, Ferreira F, Commandeur U, Fischer R, Bentrup F-W (2004). Overexpression and production of plant allergens by molecular farming strategies. Methods, 32(3): 235-40

Bauer HC, Traweger A, Bauer H (2004). Proteins of the tight junction in the blood-brain barrier. In: Blood-spinal cord and brain barriers in health and disease. Eds. Sharma H.S. and Westman J., Elsevier/Academic Press, Boston, pp: 1-10

Tontsch, S, Lepperdinger, G,Artner, I, Bauer HC (2004) Whole mount in situ hybridization: Manual and automated Procedures.. In:“Molecular Morphology in Human Tissues: Techniques and Applications“ Edt. G. Hacker, Taylor & Francis Books, Inc. pp 157-167

2003

Gadermaier G*, Gehwolf R*, Sebesta W, Pertl H, Hamilton N, Hoidn C, Ferreira F, Obermeyer G (2003). In-planta production of pollen allergens: expression of Art v 1 in virus- and Agrobacterium-transformed tobacco plants. Allergy Clin Immunol Int, Suppl 2: 1-4 (*equal contribution)

Puchert, E, Andruchov, O, Wagner, A, Grassberger, H, Lahnsteiner, F, Sobieszek, A, Galler, S (2003) Slowing effects of Mg²+ on contractile kinetics of skinned preparations of rat hearts depending on myosin heavy chain isoform content. Pflugers Arch – Eur J Physiol 447: 135-141

Traweger A, Fuchs R, Krizbai IA, Weiger TM, Bauer HC, Bauer, H (2003). The tight junction protein ZO-2 localizes to the nucleus and interacts with the heterogeneous nuclear ribonucleoprotein Scaffold Attachment Factor-B. J. Biol. Chem., 278: 2692-700

Toborek., M., Lee, Y.W., Pu, H., Malecki, A., Flora, G., Garrido, R. Hennig, B., Bauer, H.C. and Nath, A. (2003). HIV-TAT protein induces oxidative and inflammatory pathways in brain endothelium. J.Neurochem. 84 (1) 169-179

Bresgen, N., Karlhuber, G., Krizbai, I.A., Bauer, H., Bauer, H.C. and Eckl, P. (2003). Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei and apoptosis.J. Neurosci. Res. 72 (3) 327-333.

2002

Kerschbaum HH, Grissmer S, Engel E, Richter K, Lehner C, Jäger H (2002). A Shaker homologue encodes an A-type current in Xenopus laevis, 8;927(1):55-68

Gehwolf R, Griessner M, Pertl H, Obermeyer G (2002). First patch, then catch: measuring the activity and the mRNA transcripts of a proton pump in individual Lilium pollen protoplasts. FEBS Letters, 512: 152-56

Traweger A, Fang D, Liu YC, Stelzhammer W, Krizbai IA, Fresser F, Bauer HC, Bauer H (2002): The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase Itch. J. Biol. Chem., 277:10201-10208

2001

Pertl H, Himly M, Gehwolf R, Kriechbaumer R, Strasser D, Michlake W, Richter K, Ferreira F, Obermeyer G (2001). Molecular and physiological characterization of a 14-3-3 protein from lily pollen grains regulating the activity of the plasma membrane H+ ATPase during pollen grain germination and tube growth. Planta, 213: 132-41

Morcos, Y., Hosie, M.J., Bauer H.C. and Taloi Chan-Ling (2001). Immunolocalisation of occludin and claudin-1 to tight junctions in intact CNS vessers. J. Neurocytol. 30., 105-121

Tontsch, S., Zach, O., and Bauer, H. C. (2001). Identification and localization of 1A13, a mouse homologue of the human transcriptional corepressor CoREST, in the developing mouse CNS. Mech. Dev. 108/1-2, 165-169

2000

Bauer, HC and Bauer H (2000). Neural induction of the blood-brain barrier: Still an enigma. (Review) Cell.Molec.Neurobiol. 20,1, 13-28

Meerarani, P, Ramadass, P, Toborek, M, Bauer, HC, Bauer, H, Hennig, B (2000). Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis fachtor. Am. J. Clin. Nutr. 71,81-87

Webersinke, G, Bauer, HC, Danninger, C, Krizbai, I, Schittny, J, Thalhamer, J, Bauer H (2000). Genetically modified glial cells overexpressing laminin a1-chain peptides in neurite outgrowth studies. Cell. Molec.Neurobiol.20,6, 605-621

Krizbai, IA, Bauer, H, Amberger, A, Hennig, B, Szabo, H, Fuchs, R, Bauer HC (2000). Growth factor-induced morphological, physiological and molecular characteristics in cerebral endothelial cells. Europ. J. Cell Biol. 79, 594-600

Drittmittel:

2000: HC Bauer, ÖNB (6475) „ Der Einfluß bestimmter Laminin-alpha 1 Fragmente auf die Neuronaldifferenzierung und –regeneration in vitro“ (€ 18,222.-)

1999-2001: HC Bauer. FWF (13836) „Identification and Localization of 1A13, a novel gene expressed in the developing mouse“ (€ 73,825.-)

1999-2002: HC Bauer. BMfWVV (GZ70.036/2) “Oxygen free radical – induced dysfunctions of the blood-brain barrier: Relationship between oxidative stress and junctional integrity” (€ 107,999.-)

2001-2005 H. Bauer, H.C. Bauer. ÖNB (9039) “Expression of hypoxia-inducible proteins in cerebral endothelial cells in vitro: correlation of oxidative stress with blood-brain barrier impairment” (€ 58,266.6.-)

2004-2006 A Traweger; FWF – Schrödinger Stipendium “Identifikation neuer Regulatoren epithelialer Zellpolarität.“

2005-2010 HC Bauer, H Tempfer. FFG “Herstellung und Verwendung differenzierter Sehnenzellen für die Therapie von Sehnenverletzungen ” (€ 450,220.-)

2007-2008 H Resch, HC Bauer. Fonds der Boehler-Gesellschaft. „Kultivierung, Charakterisierung und Aktivierung von Sehnenzellen zur späteren Anwendung bei Sehnenverletzungen“ (€ 26,000.-)

2008-2009 H Resch, HC Bauer. Fonds der Boehler-Gesellschaft. “Histologische und molekulare Charakterisierung der alternden Supraspinatussehne” (€ 22,000.-)

2008-2010 H Tempfer, A Moder. Forschungsinstitut Gastein. „Die Rolle von CD44 und Hyaluronsäure in der Radontherapie - eine preliminäre Mausstudie (€ 36,000.-)

2009 - 2010 HC Bauer, R Gehwolf , A Wagner. PMU-FFF „ Molecular and cellular architecture of tendon and ligament: How diverse are anterior cruciate ligament and semitendinosus tendon?” (€ 39,398.-)

2009-2010 C. Hirzinger und H. Tempfer. PMU-FFF, RISE “Biomechanische Testung der Achillessehne im Rattenmodell: Funktionstest für neue Anwendungen von Sehnenvorläuferzellen” (€ 12.080.-)

2009-2010 H Resch, HC Bauer, H Tempfer. Fonds der Boehler-Gesellschaft. „Die potentielle Rolle von Tenozyten-Vorläuferzellen in der Sehnenheilung: Neue Aspekte bei der Regeneration“ (€ 24,000.-)

2010- 2011 A Harrer, R Gehwolf. PMU, RISE “Development of a bridging assay for quantifying therapeutic antibodies bound to target surface antigens - an advanced application of the new proximity ligation technology” (€ 11,480.-)

2010-2013 EU FP7. „ NEUROBID“ (€ 190,000.-)

2011-2012 HC Bauer. Straniak-Stiftung. “Beschleunigte Sehnenheilung“ (€ 15,000.-)

2011-2012 C. Lehner, HC Bauer. PMU, RISE “The neuronal repressor CoREST, a putative key to the understanding of the high regenerative potential of the olfactory epithelium” (€ 12,500.-)

2012-2013 HC Bauer. Straniak Stiftung. “Der gestörte Proteinhaushalt am choroid plexus des Großhirns – Auslöser der Alzheimer´schen Krankheit“ (€ 32,500.-)

2012-2013 R Gehwolf. PMU, RISE. “Single cell analyses to study transport processes at the choroid plexus (in situ Proximity Ligation Assay, Laser microdissection and single cell qRTPCR” (€ 12.468.-)

Kooperationen

Wissenschaftliche Kooperationen

  • ForschungsCluster für Geweberegeneration, Wien
  • Querschnitts- und Geweberegenerationszentrum Salzburg, PMU, Salzburg
  • Universitätsklinik für Unfallchirurgie und Sportmedizin, SALK, Salzburg (Univ.-Prof. Dr. Herbert Resch)
  • Institut für Biomechanik, Unfallklinik Murnau, Deutschland (Univ.-Prof. Dr. Peter Augat)
  • Institut für Molekulare Regenerative Medizin, PMU, Salzburg (Univ.-Prof. Dr. Ludwig Aigner)
  • Universitätsklinik für Kinder- und Jugendheilkunde, Laura-Bassi-Center of Expertise – THERAPREP, Forschungsprogramm für Rezeptorbiochemie und Tumorstoffwechsel, PMU, Salzburg (Univ.-Prof. Dr. Barbara Kofler)
  • Institut für Physiologie und Pathophysiologie, PMU, Salzburg (Univ.-Prof. Dr. Markus Ritter)
  • Abteilung für Organismische Biologie, Paris-Lodron-Universität Salzburg (Univ.-Doz. Dr. Hannelore Bauer)
  • Institut für Pharmakologie, Universität Melbourne, Melbourne, Victoria, Australien (Dr. Norman Saunders und Dr. Kate Dziegielewska)
  • Institut für Biophysik, Biology Research Center, Szeged, Ungarn (Dr. Istvan Krizbai)
  • Molecular and Cell Nutrition Laboratory, Universität Lexington, USA (Dr. Bernhard Hennig)
  • Leibniz-Institut für Molekulare Pharmakologie, Berlin-Buch, Deutschland (Dr. Ingolf Blasig)
  • Universitätsklinik für Geriatrie, CDK, Salzburg (Univ.-Prof. Dr. Bernhard Iglseder)
  • Spinal Cord Injury Center, Universitätsklinikum Heidelberg, Deutschland (Prof. Dr. Norbert Weidner, Prof. Dr. Armin Blesch)
  • Straniak-Stiftung, Schweiz

Industry partner

  • Arthrex Inc., Naples, USA (Dr. Marion Schrader)
  • Applied biotechnology, Salzburg (Univ.-Doz. Dr. Hannelore Bauer)

Team and contact

Priv.-Doz. Dr. Andreas Traweger
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute for Tendon and Bone Regeneration

Head

Phone: +43 662 2420-80860
Mail: andreas.traweger@pmu.ac.at
Publications
MMag. Dr. Doris Traweger
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute for Tendon and Bone Regeneration

Assistant to the Head

Phone: +43 662 2420-80861
Mail: doris.traweger@pmu.ac.at
Publications
Mag. Dr. rer. nat. Renate Gehwolf
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute for Tendon and Bone Regeneration

Research Associate

Mail: renate.gehwolf@pmu.ac.at
Publications
Moritz Grütz, MSc
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute for Tendon and Bone Regeneration

Ph.D. Student

Phone: +43 662 2420-80861
Mail: moritz.gruetz@pmu.ac.at
Stefanie Korntner, MSc
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute for Tendon and Bone Regeneration

Ph.D. Student

Phone: +43 662 2420-80868
Mail: stefanie.korntner@pmu.ac.at
Publications
Dr. med. vet. Nadja Kunkel, Dipl. Tierärztin
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute for Tendon and Bone Regeneration

Veterinary

Mail: nadja.kunkel@pmu.ac.at
Publications
Mag. Dr. Christine Lehner
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute for Tendon and Bone Regeneration

Research Associate

Phone: +43 662 2420-80867
Mail: christine.lehner@pmu.ac.at
Publications
Mag. Dr. Herbert Tempfer
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute for Tendon and Bone Regeneration

Research Associate

Phone: +43 662 2420-80864
Mail: herbert.tempfer@pmu.ac.at
Publications
Dr. Andrea Wagner
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute for Tendon and Bone Regeneration

Research Associate

Phone: +43 662 2420-80867
Mail: andrea.wagner@pmu.ac.at
Publications
Prof. Dr. Hans-Christian Bauer
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute for Tendon and Bone Regeneration

Emeritus group leader

Phone: +43 662 2420-80860
Mail: hans.bauer@pmu.ac.at
Publications