Forschung & Innovation
Publikationen
Chapter 4 - The tendinopathy triad—Mechanical stress, inflammation, and vascularity
PMU Autor*innen
Christine Lehner, Herbert Tempfer, Bettina Faustini, Renate Gehwolf, Andreas Traweger
Alle Autor*innen
Christine Lehner, Herbert Tempfer, Bettina Faustini, Renate Gehwolf, Andreas Traweger
Kurzfassung
The present chapter addresses various risk factors underlying the development of tendinopathy, with particular emphasis on mechanical stress, inflammation, and vascularity. Although all these factors per se contribute to the onset and progression of the disease, they must not be considered in isolation, as they heavily impact on each other. Therefore, this chapter aims to delineate the intricate interplay between mechanical strain, inflammatory mediators, and angiogenesis, but also seeks to include additional factors known to favour degenerative processes, such as hypoxia and fibrosis. Finally, the role of the extracellular matrix in the context of mechanosensation and mechanotransduction as a driver of tendon health and disease will be discussed.