Forschung & Innovation
Publikationen
Increased O-GlcNAcylation in Leukocytes from Overweight Pediatric Subjects
PMU Autor*in
Silvia Dossena
Alle Autor*innen
Alessia Remigante, Sara Spinelli, Gianluca Rizzo, Daniele Caruso, Angela Marino, Elisabetta Straface, Silvia Dossena, Rossana Morabito
Fachzeitschrift
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Kurzfassung
Type II diabetes mellitus (T2D) is a metabolic disorder. Childhood overweight or obesity raises the risk for developing T2D later in life. Early identification of at-risk individuals is fundamental for disease prevention and patient management. The scope of this pilot study was to explore whether leukocyte protein O-GlcNAc modification is elevated in an overweight pediatric cohort. Eight overweight and eight normal-weight children aged 3-13 years were recruited at the Papardo General Hospital (Messina, Italy). Physical exams, complete blood tests, and determination of leukocyte protein O-GlcNAcylation were carried out. Protein O-GlcNAcylation was higher in leucocytes from overweight children compared to normal-weight children, and was significantly correlated with BMI, metabolic markers (LDL-cholesterol/triglycerides), and the inflammatory marker CRP. This study suggests that leukocyte protein O-GlcNAcylation may represent a novel biomarker for the early detection of metabolic abnormalities that may lead to the development of pre-diabetes or T2D later in life.
Keywords
LEUKOCYTES, O-GlcNAcylation, Pediatric overweight, Pre-diabetes, type II diabetes mellitus