Forschung & Innovation
Publikationen
Isolated leptomeningeal infiltration of a primary CNS B-cell lymphoma diagnosed by flow cytometry and confirmed by necropsy.
PMU Autor*innen
Erasmia Broussalis, Katrin Oppermann, Peter Wipfler, Georg Pilz, Andrea Harrer, Elisabeth Haschke-Becher, Stefan Golaszewski, U. Schönauer, Monika Killer-Oberpfalzer, Eugen Trinka, Jörg Kraus
Alle Autor*innen
Erasmia Broussalis, M. Hutterer, Katrin Oppermann, Peter Wipfler, Georg Pilz, Andrea Harrer, Elisabeth Haschke-Becher, Stefan Golaszewski, U. Schönauer, S. Weis, Monika Killer-Oberpfalzer, M. Mc Coy, Eugen Trinka, Jörg Kraus
Fachzeitschrift
ACTA NEUROLOGICA SCANDINAVICA
Kurzfassung
BACKGROUND: The diagnosis of the isolated leptomeningeal involvement of a primary central nervous system B-cell lymphoma without parenchyma lesions may be difficult. Patients with leptomeningeal meningeosis lymphomatosa can present with various neurologic deficits. AIMS OF THE STUDY: To demonstrate the impact of cerebrospinal fluid (CSF) flow cytometry in the diagnosis of an isolated leptomeningeal manifestation of B-cell lymphoma by presenting an interesting case report. METHODS: Flow cytometric analysis of B-cell monoclonality of the CSF was performed as complementary diagnostic procedure in addition to CSF cytology. Final diagnosis was confirmed by necropsy. RESULTS: We suspected isolated leptomeningeal manifestation of B-cell lymphoma with palsy of the VI and VII cranial nerves in a 79-year-old male, because of mononuclear pleocytosis in CSF. Interestingly, the decisive diagnostic hint was given by implementation of flow cytometry of the CSF. Diagnosis was confirmed by postmortem autopsy. CONCLUSION: Our case shows that flow cytometry of the CSF in addition to conventional CSF cytology has the potential to accelerate diagnosis of lymphomeningeal infiltration of B-cell lymphoma.
Keywords
DISEASE, SENSITIVITY, CEREBROSPINAL-FLUID, CENTRAL-NERVOUS-SYSTEM, MALIGNANT HEMATOPOIETIC-CELLS, PRESENTING FEATURES, SOLID TUMORS, METASTASES, CYTOLOGY, CARCINOMATOSIS