Forschung & Innovation
Publikationen
Harnessing skin-resident γδ T cells for immunotherapy in cutaneous squamous cell carcinoma
PMU Autor*innen
Roland Zauner, Martin Laimer, Christina Guttmann-Gruber, Iris K Gratz
Alle Autor*innen
Giorgia Nasi, Leonie C Schöftner, Lara Ronacher, Amalia Sophianidis, Julia Feiser, Teodora Aleksandrova, Oliver Nussbaumer, Andrew Hutton, Roland Zauner, Johanna Moser-Waxenecker, Suraj R Varkhande, Anshu Sharma, Monika Ettinger, Teresa Burner, Martin Laimer, Christina Guttmann-Gruber, Iris K Gratz
Fachzeitschrift
SCIENCE ADVANCES
Kurzfassung
Gamma delta (gamma delta) T cells are critical for tissue immune surveillance and their presence in tumors correlates with a favorable prognosis, highlighting their therapeutic potential. Although gamma delta T cells are abundant in the skin, their therapeutic value in skin cancer has remained largely unexplored due to challenges in isolating sufficient numbers of gamma delta T cells from human tissues and a lack of suitable preclinical models for skin cancer. Here, we are using innovative methods to expand human cutaneous gamma delta T cells ex vivo, enabling us to investigate their therapeutic potential in a human cutaneous squamous cell carcinoma (cSCC) mouse model. In this model, gamma delta T cells were specifically recruited to and maintained in the cSCC xenograft. These tumor-infiltrating cells exhibited an activated, cytotoxic phenotype and demonstrated effective antitumor activity in vivo. Collectively, our findings provide preclinical evidence supporting human skin-resident gamma delta T cells as a promising immunotherapeutic approach for treating skin cancers such as cSCC.
Keywords
Humans, Animals, MICE, Disease Models, Animal, Cell Line, Tumor, Immunotherapy/methods, Cutaneous Squamous Cell Carcinoma/therapy, Receptors, Antigen, T-Cell, gamma-delta/metabolism, Skin Neoplasms/therapy, Skin/immunology, T-Lymphocytes/immunology, Xenograft Model Antitumor Assays, Carcinoma, Squamous Cell/therapy, Lymphocytes, Tumor-Infiltrating/immunology, Intraepithelial Lymphocytes/immunology