Forschung & Innovation
Publikationen
Tumour Associated Macrophages (TAMs): Pioneering Neural Regeneration In Vitro
PMU Autor*innen
Bruno Benedetti, Lara Sophie Bieler, Sébastien Couillard-Després
Alle Autor*innen
Giulia Pruonto, Ludovica Sagripanti, Ilaria Barone, Sissi Dolce, Eros Rossi, Loris Mannino, Francesca Ciarpella, Nicola Piazza, Benedetta Savino, Patrizia Bossolasco, Bruno Benedetti, Lara Sophie Bieler, Sébastien Couillard-Després, Guido Francesco Fumagalli, Massimo Locati, Ilaria Decimo, Francesco Bifari
Kurzfassung
Transriptomic analysis revealed that in vitro generated mouse TAMs are endowed with a specific nerve growth signature. Moreover, TAMs express genes required for wound healing, including ECM-remodelling, angiogenesis, immune modulation, detoxification and defence, response to stress and glucose metabolism even higher than in M2 macrophages.
AIM: The aim is to exploit and characterize TAMs neuro-regenerative potential. To this scope we tested TAMs: i) neurotrophic, ii) neuroprotective and iii) immunomodulatory properties