Programm Nanovesikuläre Therapien
Publikationen

Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats

Amelie Deluca, Andrea Wagner, Patrick Heimel, Christian Deininger, Florian Wichlas, Heinz Redl, Eva Rohde, Herbert Tempfer, Mario Gimona, Andreas Traweger , Humans; Female; Animals; Mesenchymal Stem Cells/metabolism; Femur/pathology; RATS; Rats, Sprague-Dawley; Disease Models, Animal; Bone Morphogenetic Protein 2/pharmacology; Recombinant Proteins/pharmacology; Osteoporosis/pathology; Umbilical Cord/cytology; Extracellular Vesicles/metabolism; Bone Regeneration/drug effects; Transforming Growth Factor beta/pharmacology; X-Ray Microtomography;

Evaluation of the Potential of Umbilical Cord Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles to Improve Rotator Cuff Healing: A Pilot Ovine Study.

Florien Jenner, Andrea Wagner, Iris Gerner, Eberhard Ludewig, Robert Trujanovic, Eva Rohde, Brigitte von Rechenberg, Mario Gimona, Andreas Traweger , STEM-CELLS; TENDON; EXOSOMES; INTERNATIONAL-SOCIETY; SECRETOME; PROMOTE;

GMP-compliant manufacturing of biologically active cell-derived vesicles produced by extrusion technology

Hui-Chong Lau, Dong Woo Han, Jinhee Park, Edwine Lehner, Carina Anna Kals, Claudia Arzt, Elisabeth Bayer, Daniela Auer, Tanja Schally, Eva Grasmann, Han Fang, Jae-Young Lee, Hyun Soo Lee, Jinah Han, Mario Gimona, Eva Rohde, Shingyu Bae, Seung Wook Oh , MESENCHYMAL STEM-CELLS; EXTRUSION; VESICLES; DRUG-DELIVERY; GMP-konforme Herstellung; cell derived vesicles; aus Zellen gewonnene Vesikel; Medikamentenverabreichungsplattform;

A CD73 ENZYME ACTIVITY ASSAY FOR STABILITY AND DOSE-FINDING OF THERAPEUTICALLY-ACTIVE EVS

Claudia Arzt, Han Fang, Eva Grasmann, Carina Anna Kals, Elisabeth Bayer, Daniela Auer, Tanja Schally, Eva Rohde, Mario Gimona

Calorimetry of extracellular vesicles fusion to single phospholipid membrane.

Miriam Grava, Sally Helmy, Mario Gimona, Pietro Parisse, Loredana Casalis, Paola Brocca, Valeria Rondelli

COMPREHENSIVE LABEL-FREE CHARACTERIZATION OF EXTRACELLULAR VESICLES AND THEIR SURFACE PROTEINS

E. Priglinger, J. Strasser, B. Buchroithner, F. Weber, S. Wolbank, Daniela Auer, Eva Grasmann, C. Arzt, MS Narzt, J. Grillari, J. Preiner, J. Jacak, Mario Gimona

Extracellular Vesicles in Inner Ear Therapies-Pathophysiological, Manufacturing, and Clinical Considerations.

Athanasia Warnecke, Hinrich Staecker, Eva Rohde, Mario Gimona, Anja Giesemann, Agnieszka J Szczepek, Arianna Di Stadio, Ingeborg Hochmair, Thomas Lenarz , MESENCHYMAL STEM-CELLS; HAIR-CELLS; HEARING-LOSS; MOLECULAR-MECHANISMS; CYTOKINE STORM; SPIRAL GANGLION NEURONS; ELECTRIC-ACOUSTIC STIMULATION; COCHLEAR IMPLANTATION; AUDITORY-SYSTEM; ATP RELEASE;

Enhancing Functional Recovery Through Intralesional Application of Extracellular Vesicles in a Rat Model of Traumatic Spinal Cord Injury.

Pasquale Romanelli, Lara Sophie Bieler, Patrick Heimel, Siniša Škokić, Dominika Jakubecova, Christina Kreutzer, Pia Zaunmair, Tomislav Smolčić, Bruno Benedetti, Eva Rohde, Mario Gimona, David Hercher, Marina Dobrivojević Radmilović, Sebastien Couillard-Despres , CELLS; EXPRESSION; INFLAMMATION; IDENTIFICATION; REGENERATION; EXOSOMES; MOLECULAR-MECHANISMS; MICROGLIA; SCAR; ASTROCYTE;

Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial.

Antonio Uccelli, Alice Laroni, Rehiana Ali, Mario Alberto Battaglia, Morten Blinkenberg, Lou Brundin, Michel Clanet, Oscar Fernandez, James Marriot, Paolo Muraro, Seyed Massood Nabavi, Roberto S Oliveri, Ernst Radue, Cristina Ramo Tello, Irene Schiavetti, Johann Sellner, Per Soelberg Sorensen, Maria Pia Sormani, Jens Thomas Wuerfel, Mark S Freedman , TRANSPLANTATION; BONE-MARROW; LUNG; MARROW STROMAL CELLS;

Structural insights into fusion mechanisms of small extracellular vesicles with model plasma membranes

F. Perissinotto, V. Rondelli, B. Senigagliesi, P. Brocca, L. Almasy, L. Bottyan, DG Merkel, H. Amenitsch, B. Sartori, Karin Pachler, M. Mayr, Mario Gimona, Eva Rohde, L. Casalis, P. Parisse

Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.

Mario Gimona, Maria Felice Brizzi, Andre Boon Hwa Choo, Massimo Dominici, Sean M Davidson, Johannes Grillari, Dirk M Hermann, Andrew F Hill, Dominique de Kleijn, Ruenn Chai Lai, Charles P Lai, Rebecca Lim, Marta Monguió-Tortajada, Maurizio Muraca, Takahiro Ochiya, Luis A Ortiz, Wei Seong Toh, Yong Weon Yi, Kenneth W Witwer, Bernd Giebel, Sai Kiang Lim , STEM-CELLS; EXOSOMES; HETEROGENEITY; MICROVESICLES PROTECT;

First-in-human intracochlear application of human stromal cell-derived extracellular vesicles.

Athanasia Warnecke, Nils Prenzler, Jennifer Harre, Ulrike Köhl, Lutz Gärtner, Thomas Lenarz, Sandra Laner-Plamberger, Georg Wietzorrek, Hinrich Staecker, Teresa Lassacher, Julia Carolin Hollerweger, Mario Gimona, Eva Rohde , IMPACT; INSERTION; HEARING PRESERVATION; COCHLEAR IMPLANTATION; MICROVESICLES PROTECT;

Label-free characterization of an extracellular vesicle-based therapeutic.

Eleni Priglinger, Juergen Strasser, Boris Buchroithner, Florian Weber, Susanne Wolbank, Daniela Auer, Eva Grasmann, Claudia Arzt, Dmitry Sivun, Johannes Grillari, Jaroslaw Jacak, Johannes Preiner, Mario Gimona , SIZE; PROTEIN; SURFACE; SPECTROSCOPY; EXOSOMES; QUARTZ-CRYSTAL MICROBALANCE; TITANIUM-OXIDE; ADSORPTION;

Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo.

Athanasia Warnecke, Jennifer Harre, Hinrich Staecker, Nils Prenzler, Dirk Strunk, Sebastien Couillard-Despres, Pasquale Romanelli, Julia Carolin Hollerweger, Teresa Lassacher, Daniela Auer, Karin Pachler, Georg Wietzorrek, Ulrike Köhl, Thomas Lenarz, Katharina Schallmoser, Sandra Laner-Plamberger, Christine S Falk, Eva Rohde, Mario Gimona , EXPRESSION; MORPHOLOGY; EAR; SURVIVAL; EXOSOMES; SPIRAL GANGLION NEURONS; NEURITE OUTGROWTH; AUDITORY NEURONS; BDNF; CULTURES;

Multi-technique analysis of extracellular vesicles: not only size matters.

F. Perissinotto, B. Senigagliesi, L. Vaccari, M. Pachetti, F. D’Amico, H. Amenitsch, B. Sartori, K. Pachler, M. Mayr, Mario Gimona, Eva Rohde, F. Caponnetto, D. Cesselli, L. Casalis, P. Parisse

SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema.

Eleni Priglinger, Karin Strohmeier, Moritz Weigl, Carolin Lindner, Daniela Auer, Mario Gimona, Martin Barsch, Jaroslaw Jacak, Heinz Redl, Johannes Grillari, Matthias Sandhofer, Matthias Hackl, Susanne Wolbank , CELLS; INJURY; EXPRESSION; FAMILY; ADIPOSE-TISSUE; MARKER; HOMEOSTASIS; EXOSOMES; CIRCULATING MICRORNAS; ROLES;

Differential fluorescence nanoparticle tracking analysis for enumeration of the extracellular vesicle content in mixed particulate solutions.

Alexandre Desgeorges, Julia Carolin Hollerweger, Teresa Lassacher, Eva Rohde, C. Helmbrecht, Mario Gimona , EXOSOMES;

Therapeutic potential of the vesicular secretome of human stromal cells

Eva Rohde, Julia Carolin Hollerweger, Teresa Lassacher, Katharina Schallmoser, J. Schulze, A. Warnecke, Pasquale Romanelli, Sébastien Couillard-Després, Andreas Traweger, Dirk Strunk, Mario Gimona

Manufacturing and characterization of extracellular vesicles from umbilical cord-derived mesenchymal stromal cells for clinical testing.

Eva Rohde, Karin Pachler, Mario Gimona , ANGIOGENESIS; US; GROWTH; Europe; MICRORNAS; EXOSOMES; INCLUDING STEM-CELLS; A METHOD; INHIBIT; PROGENY;

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

KW Witwer, BWM Van Balkom, S. Bruno, A. Choo, M. Dominici, Mario Gimona, AF Hill, D. De Kleijn, M. Koh, RC Lai, SA Mitsialis, LA Ortiz, Eva Rohde, T. Asada, WS Toh, DJ Weiss, L. Zheng, B. Giebel, SK Lim , CULTURE; TIME; EXOSOMES; RNA; FETAL BOVINE SERUM; EXPANSION; HUMAN PLATELET LYSATE; TRANSFERRIN RECEPTOR;