Research & Innovation
Publications
Total Synthesis and Configuration Assignment of (+)-Myxoquaterine-450
PMU Author
Alexander Popoff
All Authors
Johanna Löhr, Sabrina Ortmann, Alexander Popoff, Rolf Müller, Thorsten Bach
Journal association
ANGEWANDTE CHEMIE
Abstract
Myxoquaterines represent a recently discovered class of natural products with intriguing biological properties. They were isolated from Pendulasporacea albinea MSr 11954 and display a unique structure combining heterocyclic (pyrrole, oxazoline), hexaene, and 2-amino-1,3-diol subunits. We have now synthesized the first example of a myxoquaterine natural product, myxoquaterine-450, in a highly convergent fashion, in which the sensitive hexaene unit was established in the final stages of the synthesis (16 linear steps starting from l-serine). Comparison of the synthetic material with an authentic sample allowed to establish and confirm the constitution and configuration of the natural product.