Scientific Research Institutes > University Institutes > Tendon and Bone Regeneration

Institute of Tendon and Bone Regeneration

Head: Prof. Dr. Andreas Traweger



Founding

The Institute of Tendon and Bone Regeneration originates from a research initiative for cell biology and was founded at the end of 2011 by Univ.-Prof. Dr. Herbert Resch, Rector of Paracelsus Medical Private University and Senior Consultant of the University Hospital for Trauma Surgery and Sports Traumatology. This was possible by an endowment by three sponsors – Red Bull GmbH, Rauch GmbH and Rexam PLC, which have financed the institute first for five years. Univ.-Doz. Dr. Hans-Christian Bauer was entrusted as a research professor with the management of the institute for the duration of three years. The work group around Bauer was taken over in the institute and thus the long cooperation between the head of the institute, its employees and the rector was strengthened and expanded.


Objective

The name of the new institute reveals its goal: to develop new treatment strategies for defective/damaged tendons and bones, in order to restore their functionality as far as possible. These strategies have to do very often with the potential of the plastic precursor cells which differentiate themselves during the regeneration process in cells with clearly specific functions. In this way, the own healthy cells of the body can be attracted and stimulated. Alternatively, the damaged cells and tissues can be replaced by transplantation. Generally, we follow the "From Bench to Bedside" philosophy and focus primarily on the research of the fundamental mechanisms of the tendons and bone degeneration and their correction. This is done both in vitro and in vivo, in order to be able as a result to develop therapeutic strategies for tissue regeneration.

Research projects and methods

Projects

There are already several strategies that are applied in the hospital in order to accelerate the regeneration of the bones, but, as before, new ways were desirable. Certain pathological conditions in the bones can still not be explained and require scientific research. On the other hand, the regeneration of the tendons is still very little understood and in the recent decades it was often neglected. Therefore, the need to research the regeneration capabilities of the tendons is obvious – and, due to the increasing ageing of the population, is becoming even more urgent. One of the possible strategies in both tissues is the use of precursor cells. Therefore, our projects will answer the questions about the nature and the effectiveness of these cells and what significant role they can play in the regeneration. In addition, in the tendon area, the fundamental research of the tendon cells is important and also to what extent their precursor cells play a role in the healthy and the damaged tendons.

 

Currently running projects:

  • The properties of the perivascular tendon cells in vitro and in vivo
  • The effect of age and gender on the stability of the tendons and the build-up of the tendon and bone structures, in particular of the osteocytes
  • The comparison of the mesenchimales stem cells with tendon precursor cells (TDSCs)
  • Establishing the suitable animal models in order to be able to analyse the regeneration models

Sparkling Science


Project: (In)Flaming tendons: Gripping reactions in the bioreactor - impact of inflammation-related mediators on tendon health.

Tendon injuries still present a major clinical challenge for trauma and orthopedic surgeons, as they only partially regenerate and replace a fully functional tendon with more or less inferior tendon tissue with limited biomechanical properties. Tendon ruptures occur mainly in the case of predamaged tendons, unless there is excessive mechanical impact. The etiology of tendon degenerative diseases, so-called tendinopathies, is still unclear, but it appears to be multifactorial. In addition to the accumulation of mostly asymptomatic microruptures, there is increasing evidence that inflammatory processes are likely to play a role. Since many diseases associated with a systemic chronic subclinical inflammation go along with an increased risk for tendinopathies, the aim of the present study is to investigate the impact of inflammatory factors e.g. cytokines on tendon quality. To this end, flexor tendons of rats and tendon cell-seeded scaffolds are being cultivated in a bioreactor for several days under cyclic strain and under exposition to defined amounts of added cytokines. This bioreactor culture system has previously been constructed in collaboration with the „Höheren Technischen Bundeslehr- und Versuchsanstalt” (HTBLuVA Salzburg; training focus: electronics & computer engineering). Both tendons and factors released into the cell culture medium by the tendon cells will then be analyzed with the aid of various molecular biological and immunohistochemical methods. In order to standardize the addition and removal of medium enriched with factors, a software-controlled, automated sample addition- or removal device will be planned and implemented by the students. This device will make it possible to automatically add or remove defined sample volumes at certain time points and store them in a frozen state until the final sample preparation. Moreover, a laser-optics-based measuring device for the exact determination of the tendon cross sectional area is built, which allows calculating the modulus of elasticity, a dimension-independent measure of stiffness.

Based on the results of these analyses, we hope to gain an improved understanding of the effects of inflammatory factors on tendon quality and thus a basis for possible therapeutic interventions.

 

 

Kooperationen

Wissenschaftliche Kooperationen

  • ForschungsCluster für Geweberegeneration, Wien
  • Querschnitts- und Geweberegenerationszentrum Salzburg, PMU, Salzburg
  • Universitätsklinik für Unfallchirurgie und Sportmedizin, SALK, Salzburg (Univ.-Prof. Dr. Herbert Resch)
  • Institut für Biomechanik, Unfallklinik Murnau, Deutschland (Univ.-Prof. Dr. Peter Augat)
  • Institut für Molekulare Regenerative Medizin, PMU, Salzburg (Univ.-Prof. Dr. Ludwig Aigner)
  • Universitätsklinik für Kinder- und Jugendheilkunde, Laura-Bassi-Center of Expertise – THERAPREP, Forschungsprogramm für Rezeptorbiochemie und Tumorstoffwechsel, PMU, Salzburg (Univ.-Prof. Dr. Barbara Kofler)
  • Institut für Physiologie und Pathophysiologie, PMU, Salzburg (Univ.-Prof. Dr. Markus Ritter)
  • Abteilung für Organismische Biologie, Paris-Lodron-Universität Salzburg (Univ.-Doz. Dr. Hannelore Bauer)
  • Institut für Pharmakologie, Universität Melbourne, Melbourne, Victoria, Australien (Dr. Norman Saunders und Dr. Kate Dziegielewska)
  • Institut für Biophysik, Biology Research Center, Szeged, Ungarn (Dr. Istvan Krizbai)
  • Molecular and Cell Nutrition Laboratory, Universität Lexington, USA (Dr. Bernhard Hennig)
  • Leibniz-Institut für Molekulare Pharmakologie, Berlin-Buch, Deutschland (Dr. Ingolf Blasig)
  • Universitätsklinik für Geriatrie, CDK, Salzburg (Univ.-Prof. Dr. Bernhard Iglseder)
  • Spinal Cord Injury Center, Universitätsklinikum Heidelberg, Deutschland (Prof. Dr. Norbert Weidner, Prof. Dr. Armin Blesch)
  • Straniak-Stiftung, Schweiz

Industry partner

  • Arthrex Inc., Naples, USA (Dr. Marion Schrader)
  • Applied biotechnology, Salzburg (Univ.-Doz. Dr. Hannelore Bauer)

Team and contact

Prof. Dr. Andreas Traweger
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Head
Research Professorship for Regeneration Biology


Phone: +43 662 2420-80860
Mail: andreas.traweger@pmu.ac.at
Publications
MMag. Dr. Doris Traweger
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Assistant to the Head

Phone: +43 662 2420-80861
Mail: doris.traweger@pmu.ac.at
Publications
Mag. Dr. rer. nat. Renate Gehwolf
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Research Associate

Phone: +43 662 2420-80865
Mail: renate.gehwolf@pmu.ac.at
Publications
Dr. med. vet. Nadja Weißenbacher, Dipl. Tierärztin
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Veterinary

Phone: +43 662 2420-80868
Mail: nadja.weissenbacher@pmu.ac.at
Publications
MMag. Dr. Christine Lehner
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Research Associate

Phone: +43 662 2420-80867
Mail: christine.lehner@pmu.ac.at
Publications
Mag. Dr. Herbert Tempfer
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Research Associate

Phone: +43 662 2420-80864
Mail: herbert.tempfer@pmu.ac.at
Publications
Mag. Dr. Andrea Wagner
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Research Associate

Phone: +43 662 2420-80867
Mail: andrea.wagner@pmu.ac.at
Publications
Prof. Dr. Hans-Christian Bauer
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Emeritus group leader

Phone: +43 662 2420-80860
Mail: hans.bauer@pmu.ac.at
Publications
Gabriel Spitzer, MSc
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Ph.D.-Student

Phone: +43 662 2420-80868
Mail: gabriel.spitzer@pmu.ac.at
Publications
Bettina Schwemberger
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Ph.D.-Student

Phone: +43 662 2420-80866
Mail: b.schwemberger@pmu.ac.at
Lisa Sturm
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Graduand

Phone: +43 662 2420-80875
Mail: lisa.sturm@pmu.ac.at
Priv.-Doz. Dr. Hannelore Bauer
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Research Associate

Phone: +43 662 2420-80861
Mail: hannelore.bauer@sbg.ac.at
Dr. med. Ghada Atta
Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Institute of Tendon and Bone Regeneration

Ph.D.-Student

Phone: +43 2420-80875