Institut für Wirbelsäulenforschung
Publikationen

CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro

Iker Martinez-Zalbidea, Gabbie Wagner, Nea Bergendahl, Addisu Mesfin, Varun Puvanesarajah, Wolfgang Hitzl, Stefan Schulze, Karin Wuertz-Kozak , REGENERATION; EXOSOMES; PROTEOMICS; Genomic engineering; Ivd; Transcriptomic modulation;

The underlying mechanisms of the association of bone health with depression - an experimental study

Sanne Paulien Houtenbos, Yangyang He, Petra Cazzanelli, George Soultoukis, Karin Wuertz-Kozak, Tim J. Schulz, Pia-Maria Wippert , Bone turnover markers; Molecular mechanisms; Stress-related disorders;

Bandscheibenvorfall (Teil 2)

Dorothea Daentzer, Christoph J. Siepe

Bandscheibenvorfall (Teil 1)

Dorothea Daentzer, Christoph J. Siepe

Die lumbale Spinalkanalstenose

Franziska C. Heider, Christoph J. Siepe

Lumbaler Bandscheibenvorfall

F. C. Heider, C. J. Siepe , LUMBAR SPINE; SURGICAL DECOMPRESSION; Minimally invasive surgery; Nerve root compression; Surgical procedures (endoscopic/microsurgical);

Endoskopische Bandscheibenchirurgie

Christoph Siepe , Endoskopie; Wirbelsäule; Bandscheibenvorfall; Spinalkanalstenose; Minimalinvasive Chirurgie;

Correction: Bermudez-Lekerika et al. Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems. (vol 10,330, 2024)

Paola Bermudez-Lekerika, Katherine B. Crump, Karin Wuertz-Kozak, Christine L. Le Maitre, Benjamin Gantenbein

Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems

Paola Bermudez-Lekerika, Katherine B. Crump, Karin Wuertz-Kozak, Christine L. Le Maitre, Benjamin Gantenbein , INTERVERTEBRAL DISC; 3D culture; Cell viability; qPCR; Sulfation alginate;

Do TLIF and PLIF Techniques Differ in Perioperative Complications? - Comparison of Complications Rates of Two High Volume Centers

Christoph Mehren, N. Ostendorff, G. Schmeiser, L. Papavero, R. Kothe

Could the different surgical goals of fusion and non-fusion also be achieved in combination within the same patient?

Franziska Heider, Maria Kamenova, Lorenz Wanke-Jellinek, Christoph Siepe, Christoph Mehren

Aloe vera-based biomaterial ink for 3D bioprinting of wound dressing constructs

MC Ceballos-Santa, A. Sierra, IM Zalbidea, E. Lazarus, V. Marin-Montealegre, S. Ramesh, P. Iglesias, K. Wuertz-Kozak, IV Rivero , Biocompatible Materials/pharmacology; tissue engineering; Chitosan; Aloe vera; Extrusion-based bioprinting; Hydrogels; Skin tissue regeneration; Wound dressing; HYDROGEL FILMS; ALGINATE; Bioprinting; Bandages; Ink; Aloe/chemistry; Hydrogels/pharmacology; Tissue Scaffolds/chemistry; Printing, Three-Dimensional;

Full-endoscopic bilateral over-the-top decompression in lumbar central stenosis: surgical technique and outcomes.

Christoph Siepe, Anna-Lena Bridts, Mohamed Ayman, Daniel Sauer, Christoph Mehren , Humans; Treatment Outcome; LEARNING-CURVE; SPINAL STENOSIS; INTERLAMINAR APPROACH; UNILATERAL LAMINOTOMY; Lumbar Vertebrae/surgery; Constriction, Pathologic/surgery; Spinal Stenosis/surgery; Laminectomy/methods; Decompression, Surgical/methods;

Full-Endoscopic Lumbar Discectomy Approach Selection: A Systematic Review and Proposed Algorithm.

Vit Kotheeranurak, Wongthawat Liawrungrueang, Javier Quillo-Olvera, Christoph Siepe, Zhen Zhou Li, Pramod V Lokhande, Gun Choi, Yong Ahn, Chien-Min Chen, Kyung-Chul Choi, Facundo Van Isseldyk, Vincent Hagel, Sairyo Koichi, Christoph P Hofstetter, David Del Curto, Yue Zhou, Chen Bolai, Jun Seok Bae, Muhammed Assous, Guang-Xun Lin, Khanathip Jitpakdee, Yanting Liu, Jin-Sung Kim , Humans; SURGERY; DECOMPRESSION; Treatment Outcome; CLINICAL-OUTCOMES; Retrospective Studies; DISKECTOMY; SURGICAL TECHNIQUE; L5-S1 DISC HERNIATION; INTERLAMINAR APPROACH; LOCAL-ANESTHESIA; MICRODISCECTOMY; FORAMINOPLASTY; FORAMINOTOMY; Lumbar Vertebrae/surgery; Intervertebral Disc Displacement/surgery; Diskectomy, Percutaneous; Endoscopy;

Spondylodiscitis in Geriatric Patients: What Are the Issues?

Christian Herren, Nicolas Heinz von der Hoeh, Stefan Zwingenberger, Daniel Sauer, Norma Jung, Philipp Pieroh, Steffen Drange, Matthias Pumberger, Max J Scheyerer , OUTCOMES; MANAGEMENT; DIAGNOSIS; EFFICACY; ELDERLY-PATIENTS; POSTERIOR; BIOPSIES; PYOGENIC VERTEBRAL OSTEOMYELITIS; TUBERCULOUS SPONDYLODISCITIS; SPINAL INFECTIONS;

Computer-assisted simulated workplace-based assessment in surgery: application of the universal framework of intraoperative performance within a mixed-reality simulation.

Philipp Stefan, Michael Pfandler, Aljoscha Kullmann, Ulrich Eck, Amelie Koch, Christoph Mehren, Anna von der Heide, Simon Weidert, Julian Fürmetz, Ekkehard Euler, Marc Lazarovici, Nassir Navab, Matthias Weigl , TECHNOLOGY; Minimally invasive surgical procedures; Outcomes research;

Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily

T. Bitterli, D. Schmid, L. Ettinger, O. Krupkova, FC Bach, MA Tryfonidou, BP Meij, A. Pozzi, F. Steffen, K. Wuertz-Kozak, LA Smolders , CELLS; EXPRESSION; PATHOGENESIS; INFLAMMATION; DOG; LOW-BACK-PAIN; INTERVERTEBRAL DISC; DEATH; CYTOKINES; NERVE GROWTH-FACTOR; back pain; degenerative disc disease; nerve growth factor; RANKL; tumor necrosis factor superfamily; LIGAMENTUM-FLAVUM; HERNIATION;

Hydrogel Composite Layering Process for Full Thickness Skin Models

S.E. Sarles, E. Lazarus, L. Widom, K. Wuertz-Kozak, I.V. Rivero

Immuno-Modulatory Effects of Intervertebral Disc Cells.

Paola Bermudez-Lekerika, Katherine B Crump, Sofia Tseranidou, Andrea Nüesch, Exarchos Kanelis, Ahmad Alminnawi, Laura Baumgartner, Estefano Muñoz-Moya, Roger Compte, Francesco Gualdi, Leonidas G Alexopoulos, Liesbet Geris, Karin Wuertz-Kozak, Christine L Le Maitre, Jérôme Noailly, Benjamin Gantenbein , IN-VITRO MODEL; STEM-CELLS; NUCLEUS PULPOSUS CELLS; ANIMAL-MODELS; LOW-BACK-PAIN; CHARITE(TM) ARTIFICIAL DISC; ISSLS PRIZE WINNER; CARTILAGE END-PLATE; INTERMEDIATE LAYER PROTEIN; AGGRECAN GENE POLYMORPHISM;

Clinical and radiological mid- to long-term investigation of anterior lumbar stand-alone fusion: Incidence of reoperation and adjacent segment degeneration.

Katrin Stosch-Wiechert, Karin Wuertz-Kozak, Wolfgang Hitzl, Ulrike Szeimies, Axel Stäbler, Christoph Siepe , FOLLOW-UP; RISK-FACTORS; FACET-JOINT VIOLATION; INTERBODY FUSION; INSTRUMENTED LUMBAR; LUMBOSACRAL FUSION; DISC DEGENERATION; SACROILIAC JOINT; NONSURGICAL TREATMENT; PEEK CAGE;