Research & Innovation
Publications
Aloe vera-based biomaterial ink for 3D bioprinting of wound dressing constructs
PMU Author
K. Wuertz-Kozak
All Authors
MC Ceballos-Santa, A. Sierra, IM Zalbidea, E. Lazarus, V. Marin-Montealegre, S. Ramesh, P. Iglesias, K. Wuertz-Kozak, IV Rivero
Journal association
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Abstract
This study emphasizes the development of a multifunctional biomaterial ink for wound healing constructs. The biomaterial ink benefits from Aloe vera's intrinsic biocompatible, biodegradable, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory attributes, thus alleviating the need for supplementary substances employed to combat infections and stimulate tissue regeneration. Moreover, this biomaterial ink seeks to address the scarcity of standardized printable materials possessing adequate biocompatibility and physicochemical properties, which hinder its widespread clinical adoption. The biomaterial ink was synthesized via ionic crosslinking to enhance its rheological and mechanical characteristics. The findings revealed that Aloe vera substantially boosted the hydrogel's viscoelastic behavior, enabling superior compressive modulus and the extrusion of fine filaments. The bioprinted constructs exhibited desirable resolution and mechanical strength while displaying a porous microstructure analogous to the native extracellular matrix. Biological response demonstrated no detrimental impact on stem cell viability upon exposure to the biomaterial ink, as confirmed by live/dead assays. These outcomes validate the potential of the developed biomaterial ink as a resource for the bioprinting of wound dressings that effectively foster cellular proliferation, thereby promoting enhanced wound healing by leveraging Aloe vera's inherent properties.
Keywords
Biocompatible Materials/pharmacology, tissue engineering, Chitosan, Aloe vera, Extrusion-based bioprinting, Hydrogels, Skin tissue regeneration, Wound dressing, HYDROGEL FILMS, ALGINATE, Bioprinting, Bandages, Ink, Aloe/chemistry, Hydrogels/pharmacology, Tissue Scaffolds/chemistry, Printing, Three-Dimensional