Research & Innovation
Publications
Clinical Outcomes Associated with Intra-Articular Adipose-Derived Mesenchymal Stem Cells in Arthroscopic Repair of Rotator Cuff Tears with Concomitant Chondropathy
All Authors
Guido Bocchino, Vincenzo Campana, Riccardo Totti, Chiara Barbieri, Alessandro El Motassime, Giacomo Capece, Fjorela Qordja, Domenico Marotta, Giulio Maccauro, Vincenzo De Santis
Journal association
Applied Sciences-Basel
Abstract
Background: Osteoarthritis involves the degeneration of cartilage, subchondral bone, and the synovial membrane, often associated with rotator cuff (RC) tears, causing pain and functional limitations. While non-surgical treatments can provide relief, surgery is sometimes necessary. Autologous adipose-derived mesenchymal stem cells (ADMSCs) have shown promise in tissue repair. Objective: This study compared clinical outcomes between patients treated with arthroscopic RCR alone and those treated with RCR combined with intra-articular AdMSC injection. Methods: This retrospective study included 61 patients. Group A (n = 30) underwent standard RCR, while Group B (n = 31) received RCR combined with intra-articular ADMSC injections. Participants had comparable baseline age, BMI, height, CMS, and VAS scores. Shoulder function was assessed using the Constant-Murley Score, and pain intensity was assessed using the visual analog scale at baseline, 3, 6, and 12 months. Statistical significance was set at p < 0.05. Results: At 3 months, Group B showed lower VAS scores than Group A (13.09 +/- 8.34 vs. 25.14 +/- 13.57, p < 0.001), while CMSs did not differ significantly (70.55 +/- 23.46 vs. 63.01 +/- 24.33, p = 0.223). At 6 months, Group B showed better VAS and CMSs than Group A (VAS: 5.31 +/- 4.38 vs. 23.74 +/- 15.72, p < 0.001; CMS: 83.29 +/- 18.98 vs. 65.66 +/- 11.58, p < 0.001). At 12 months, Group B maintained better VAS and CMSs than Group A (VAS: 4.45 +/- 5.67 vs. 18.34 +/- 12.65, p < 0.001; CMS: 85.55 +/- 13.12 vs. 66.36 +/- 9.38, p < 0.001). Conclusions: In this preliminary retrospective non-randomized cohort, AdMSC use as an adjunct to arthroscopic rotator cuff repair was associated with better pain and functional scores over 12 months. Because of the retrospective design and lack of imaging follow-up, these findings should be interpreted as clinical associations and require confirmation in randomized studies.
Keywords
VISUAL ANALOG SCALE, Constant-Murley Score, Arthroscopic surgery, Autologous adipose tissue, Orthobiologics, Shoulder chondropathy