Research & Innovation
Publications
Vascular Dynamics in Tendon Health and Pathology
PMU Authors
H. Tempfer, A. Traweger
All Authors
H. Tempfer, A. Traweger
Journal association
EUROPEAN CELLS & MATERIALS
Abstract
Tendons are bradytrophic tissues, characterized by a dense extracellular matrix in their core, low cellularity, and limited vascularization under healthy conditions. Upon sustaining injury or undergoing degenerative changes, matrix quality decreases and generally a hypervascular, fibrotic scar tissue forms. The significance of angiogenesis in this context remains a topic of ongoing debate and investigation. This review focuses on the vasculature of healthy tendon tissue and the angiogenic mechanisms involved in tendinopathy, with a particular emphasis on Achilles tendon tendinopathy. Furthermore, this narrative review discusses the ongoing controversy surrounding the potential benefits of either promoting or limiting vascular supply in tendon healing.
Keywords
ANGIOGENESIS, VEGF, ACHILLES TENDINOPATHY, Tendon vasculature