Institute of Pharmacology and Toxicology
Publications

Inhibitors of the ubiquitin‑proteasome system rescue cellular levels and ion transport function of pathogenic pendrin (SLC26A4) protein variants

Emanuele Bernardinelli, Rapolas Jamontas, Arnoldas Matulevičius, Florian Huber, Houssein Nasser, Sophie Klaus, Haixia Zhu, Jiangang Gao, Silvia Dossena , Humans; Animals; MICE; HEK293 Cells; MUTATION; Proteasome Endopeptidase Complex/metabolism; Sulfate Transporters/metabolism; Ion Transport/drug effects; Proteasome Inhibitors/pharmacology; Ubiquitin/metabolism; Hearing Loss, Sensorineural/metabolism; Goiter, Nodular/metabolism; Proteolysis/drug effects;

Acai berry extract preserves human erythrocyte integrity from aging-induced oxidative stress: role of anion exchanger 1.

Sara Spinelli, Silvia Dossena, Angela Marino, Elisabetta Straface, Rossana Morabito, Alessio Remigante

Novel genetic determinants contribute to hearing loss in a central European cohort with enlarged vestibular aqueduct

Emanuele Bernardinelli, Raffaella Liuni, Rapolas Jamontas, Paola Tesolin, Anna Morgan, Giorgia Girotto, Sebastian Roesch, Silvia Dossena , Humans; Male; Female; Alleles; MUTATION; Cohort Studies; CHILD; ADOLESCENT; Child, Preschool; Infant; ADULT; Young Adult; Polymorphism, Single Nucleotide; Vestibular Aqueduct/abnormalities; Sulfate Transporters/genetics; DNA Copy Number Variations; Hearing Loss, Sensorineural/genetics; Exome Sequencing; Genetic Predisposition to Disease; POU Domain Factors/genetics; Membrane Transport Proteins/genetics; Goiter, Nodular/genetics; Connexin 26/genetics; Hearing Loss/genetics;

Iron Overload-Related Oxidative Stress Leads to Hyperphosphorylation and Altered Anion Exchanger 1 (Band 3) Function in Erythrocytes from Subjects with β-Thalassemia Minor

Sara Spinelli, Elisabetta Straface, Lucrezia Gambardella, Daniele Caruso, Silvia Dossena, Angela Marino, Rossana Morabito, Alessia Remigante , Humans; Male; Female; Reactive Oxygen Species/metabolism; Phosphorylation; OXIDATIVE STRESS; ADULT; Young Adult; Anion Exchange Protein 1, Erythrocyte/metabolism; beta-Thalassemia/metabolism; Erythrocytes/metabolism; Iron Overload/metabolism; Lipid Peroxidation;

Neue Ansätze zur Untersuchung der Rolle des Pendrin Proteins bei der Pathogenese von Erkrankungen im HNO Bereich.

Sebastian Rösch, Kathrin Renner, Lennart Weitgasser, Emanuele Bernardinelli, Silvia Dossena

Cisplatin-Induced Hearing Loss, Oxidative Stress, and Antioxidants as a Therapeutic Strategy-A State-of-the-Art Review

Olaf Rose, Tim Croonenberg, Stephanie Clemens, Tobias Hinteregger, Stefanie Eppacher, Petra Huber-Cantonati, Marta Garcia-Miralles, Raffaella Liuni, Silvia Dossena , OXIDATIVE STRESS; ANTIOXIDANTS; CISPLATIN; cisplatin-induced hearing loss (CIHL); Hearing loss; Ototoxicity;

Oxidative Stress and Antioxidants in Aging

Silvia Dossena, Angela Marino , POLYPHENOLS; HEARING;

Challenges in the diagnosis of patients with nonsyndromic hearing loss, enlarged vestibular aqueduct and Pendred syndrome.

Marek Sklenár, Silvia Borecká, Lukás Varga, Emanuele Bernardinelli, Diana Ugorová, Silvia Dossena, Daniela Gasperiková

Challenges in the diagnosis of patients with nonsyndromic hearing loss, enlarged vestibular aqueduct and Pendred syndrome.

Marek Sklenár, Silvia Borecká, Lukás Varga, Emanuele Bernardinelli, Diana Ugorová, Silvia Dossena, Daniela Gasperiková

Pathophysiological role of SLC26A4 (pendrin) in the inner ear

Silvia Dossena

Genetic analysis reveals novel variants in a cohort of patients affected by sensorineural hearing loss and Enlarged Vestibular Aqueduct (EVA).

Emanuele Bernardinelli, Raffaella Liuni, Florian Huber, Sebastian Rösch, Giorgia Girotto, Silvia Dossena

Anion exchanger 1/AE1 function is compromised in red blood cells from prediabetic subjects: beneficial effects of finger lime (Citrus australasica, Faustrime cultivar) juice extract

Alessia Remigante, S. Spinelli, E. Straface, D. Caruso, Silvia Dossena, Rossana Morabito, Angela Marino

Melatonin restores Kv3.1/KCNC1 channel function in an oxidative stress-related model of cellular aging.

Alessia Remigante, S. Spinelli, Raffaella Liuni, Angela Marino, Rossana Morabito, Silvia Dossena

Melatonin restores Kv3.1/KCNC1 channel function in an oxidative stress-related model of cellular aging.

Alessia Remigante, S. Spinelli, Raffaella Liuni, Angela Marino, Rossana Morabito, Silvia Dossena

Anion exchanger 1/AE1 function is compromised in red blood cells from prediabetic subjects: beneficial effects of finger lime (Citrus australasica, Faustrime cultivar) juice extract

Alessia Remigante, S. Spinelli, E. Straface, D. Caruso, Silvia Dossena, Rossana Morabito, Angela Marino

Anion exchanger1 (AE1/SLC4A1) function is impaired in red blood cells from prediabetic subjects

Alessia Remigante, Sara Spinelli, Lucrezia Gambardella, Elisabetta Straface, Giovanna Cafeo, Marina Russo, Daniele Caruso, Paola Dugo, Silvia Dossena, Angela Marino, Rossana Morabito , OXIDATIVE STRESS; Glycation; Hyperglycemia; Red blood cells;

Internalization of nano- and micro-plastics in human erythrocytes leads to oxidative stress and estrogen receptor-mediated cellular responses

Alessia Remigante, Sara Spinelli, Lucrezia Gambardella, Giuseppina Bozzuto, Rosa Vona, Daniele Caruso, Valentina Villari, Tiziana Cappello, Maria Maisano, Silvia Dossena, Angela Marino, Rossana Morabito, Elisabetta Straface

Pathogenic pendrin (SLC26A4) variants are functionally rescued by carfizomib.

Houssein Nasser, Emanuele Bernardinelli, Florian Huber, Martin Jakab, Sebastian Rösch, Silvia Dossena

A new mouse model of DFNB4/Pendred syndrome: CBA/J-Slc26a4 p.R409H/p.R409H

Emanuele Bernardinelli, Sebastian Rösch, Martin Jakab, Silvia Dossena

Elucidating the degradation pathway of wild-type pendrin and its pathogenic variants

Florian Huber, Emanuele Bernardinelli, Raffaella Liuni, Martin Jakab, Sebastian Rösch, Silvia Dossena