Article published in Journal of Biomedical Science (Springer Nature)
August 24, 2026: Article published in Journal of Biomedical Science (Springer Nature)
The study finds that the ZBTB16/CUL3/ROC1 ubiquitin ligase complex directly drives the accelerated degradation of pathogenic pendrin (SLC26A4) protein variants, revealing the precise molecular mechanism underlying protein loss-of-function in Pendred syndrome and genetic hearing loss. By seamlessly combining diverse experimental biology techniques with advanced AI-based structural modeling, this interdisciplinary collaboration successfully maps complex molecular interactions to pinpoint novel targets for therapeutic intervention. At PMU, this work was supported by the Research and Innovation Fund (PMU-RIF 2022-Iif-004-DOSSENA, FIZ RM&NT Talent Pool Senior Researcher 042023, and 2025-SEED-084-Dossena).
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